Abstract：Objective To investigate the effects of vitamin D administration 7 days after birth and vitamin D administration 10 days after birth on bronchopulmonary dysplasia (BPD), blood gas analysis, inflammatory factors, and lung injury index in preterm infants with very low birth weight. Methods A total of 80 preterm infants with very low birth weight admitted to our hospital from December 2021 to December 2022 were randomly selected as the study subjects, and the odd-numbered children were included in the observation group and the even-numbered children were included in the control group, with 40 cases in each group. The observation group was given 800 units of vitamin D on the 7th day after birth, and the control group was given 800 units of vitamin D on the 10th day after birth, and the incidence of BPD, blood gas analysis, inflammatory factors, and lung injury indexes of the two groups were compared. Results The incidence of BPD in the observation group was 5.00%, which was lower than that in the control group (22.50%) (χ2=5.165, P=0.023). After treatment, the PaO2 in the observation group was (97.91±32.62) mmHg, a/APO2 was (0.48±0.15), and 25(OH)D3 was (14.63±4.86) ng/mL, which was higher than those in the control group: (82.16±27.37) mmHg, (0.37±0.11), (10.84±3.60) ng/ mL, the differences were statistically significant (all P<0.05). In the observation group, PaCO2 levels were (31.13±10.36) mmHg, OI was (10.13±3.36), TNF-α was (90.63±15.09) pg/mL, IL-6 was (80.91±13.47) pg/mL, CRP was (7.58±2.51) mg/L, and sNGAL was (90.82±The 14.56) μg/L, and TGF-β1 were (9.08±3.02) ng/mL, which were lower than those of the control group: (43.04±14.33) mmHg, (17.49±5.82), (123.84±20.63) pg/mL, (115.16±19.18) pg/mL, (19.17±16.38) mg/L, (110.16±18.35) μg/L, and (21.43±7.13) ng/mL, the differences were statistically significant (all P<0.05). Conclusion Compared with vitamin D supplementation on the 10th day, vitamin D administration on the 7th day after birth can maintain the stabilityof blood gas indexes, reduce inflammation and lung tissue damage, and reduce the overall incidence of BPD.
邓磊,李思杰,刘玮,陈燕梅,张寅. 维生素D不同给药时间对极低出生体质量早产儿支气管肺发育不良的影响[J]. 中国校医, 2024, 38(1): 65-67,75.
DENG Lei, LI Sijie, LIU Wei, CHEN Yanmei, ZHANG Yin. Effect of different administration time of vitamin D on bronchopulmonary dysplasia in preterm infants with very low birth weight. Chinese Journal of School Doctor, 2024, 38(1): 65-67,75.
2024, Vol. 38 
