维生素D在小儿反复呼吸道感染治疗中的作用

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摘要目的探究维生素D在小儿反复呼吸道感染治疗中的应用效果。方法选取2022年1—12月徐州市妇幼保健院收治的68例反复呼吸道感染患儿,随机分为研究组(n=34)和对照组(n=34),对照组应用常规对症治疗、研究组在常规对症基础上补充维生素D,比较2组患儿治疗效果。结果治疗前2组患儿血清25羟基维生素D3及免疫球蛋白水平(IgA、IgG水平)对比差异无统计学意义(P>0.05),研究组治疗后患儿血清25羟基维生素D3[(21.03±3.41)ng/mL]、IgA[(3.11±0.32)g/L]、IgG[(11.62±1.39)g/L水平高于对照组[(18.25±3.26)ng/mL、(2.92±0.24)g/L、(10.22±1.46)g/L],差异有统计学意义(t值分别为3.436、2.770、4.050,P值分别为0.001、0.007、0.001); 研究组患儿咳嗽、鼻塞、发热、流涕症状消失时间均短于对照组,差异有统计学意义(t值分别为2.054、3.659、2.820、2.950;P值分别为0.044、0.001、0.006、0.004)。结论通过积极抗炎并补充维生素D可提高血清25羟基维生素D3水平,提高患儿免疫功能,改善患儿症状。

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	姚刘艳

关键词 ：小儿反复呼吸道感染, 血清25羟基维生素D3, 免疫球蛋白

Abstract：Objective To explore the effect of vitamin D in the treatment of children with recurrent respiratory tract infections. Methods A total of 68 children with recurrent respiratory tract infections admitted to Xuzhou Maternal and Child Health Hospital from January to December 2022 were randomly divided into a study group (n=34) and a control group (n=34). The control group received routine symptomatic treatment, while the study group received vitamin D supplementation on the basis of routine symptomatic treatment. The treatment effects of the two groups were compared. Results There was no significant difference in serum 25-hydroxyvitamin D3 and immunoglobulin levels (IgA, IgG) between the two groups before treatment (P>0.05), but after treatment in the study group, serum 25-hydroxyvitamin D3 , IgA , and IgG were higher than those in the control group: , the differences were statistically significant (t=3.436, 2.770, 4.050, P=0.001, 0.007, 0.001). The disappearance time of cough, nasal congestion, fever, and runny nose in the study group was shorter than those in the control group, and the differences were statistically significant (t=2.054, 3.659, 2.820, 2.950; P=0.044, 0.001, 0.006, 0.004, all P<0.05). Conclusion The serum 25-hydroxyvitamin D3 level, immune function, and symptom level can be improved through active anti-inflammatory treatment and vitamin D supplementation.

Key words： Recurrent respiratory tract infections in child Serum 25 hydroxyvitamin D3 Immunoglobulin

收稿日期: 2023-08-28

ZTFLH:

Q565

作者简介: 姚刘艳(1982—),女,江苏徐州人,副主任医师,硕士研究生,主要研究方向为儿科呼吸疾病。

引用本文:

姚刘艳. 维生素D在小儿反复呼吸道感染治疗中的作用[J]. 中国校医, 2023, 37(11): 862-865.
YAO Liuyan. Effect of vitamin D in treatment of recurrent respiratory tract infections in young children. Chinese Journal of School Doctor, 2023, 37(11): 862-865.

链接本文:

https://www.zgxyzz.org.cn/CN/ 或 https://www.zgxyzz.org.cn/CN/Y2023/V37/I11/862

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