Abstract：Objective To study the risk factors of abnormally high 25-hydroxyvitamin D levels at birth in late preterm infants, and observe the effects of the conventional treatment. Methods A total of 100 late preterm infants who were hospitalized in the neonatal ward of Shizuishan First People's Hospital from January 2017 to June 2020 were selected. According to their 25-(OH) D levels, they were divided into a deficiency group (66 cases) and an adequate group (34 cases). By using logistic regression analysis, the risk factors that affect the abnormal 25-(OH) D levels of late preterm infants at birth were clarified, and the deficiency group was treated with the conventional method and the clinical effect was observed after the treatment. Results The proportion (90.9%, 60/66) of late-born premature infants in winter and spring of the deficient group was higher than that (27.78%, 10/34) of the adequate group (χ2=40.413, P<0.001); the maternal gestational age of the deficient group was greater than that of the sufficient group (χ2=2.134, P=0.035); the maternal body mass index (BMI) of the deficient group was higher than that of the sufficient group (t=6.534, P<0.001). Logistic regression analysis showed that birth in winter and spring (OR=2.659, 95%CI 2.303-3.015, P<0.001), mother's gestational age (OR=3.425, 95%CI 2.064-4.785, P=0.002), mother's BMI (OR=2.136, 95%CI 0.491-3.781, P=0.006), and 25-(OH) D deficiency in late preterm infants were related high-risk factors. The 25-(OH) D level of late preterm infants in the deficiency group at 3 months of age was higher than that within 24 hours of birth (t=40.025, P<0.001), and compared with the adequate group at 3 months old, there was no significant difference (t=0.992, P=0.32). Conclusion Birth in winter and spring, mother's gestational age, and mother's BMI are risk factors that affect the 25-(OH) D level of late preterm infants. After the treatment, the 25-(OH) D level of preterm infants can return to normal.
王洪波,王燕玲,贺瑞荣,张秋丽,蔡娟,周建生. 晚期早产儿出生时25-羟基维生素D水平异常高危因素及疗效分析[J]. 中国校医, 2021, 35(11): 827-829.
WANG Hong-bo, WANG Yan-ling, HE Rui-rong, ZHANG Qiu-li, CAI Juan, ZHOU Jian-sheng. Analysis of high risk factors and curative effect of abnormal 25-(OH) D levels at birth in late preterm infants. Chinese Journal of School Doctor, 2021, 35(11): 827-829.
2021, Vol. 35 
