Abstract：Objective To detect plasma vitamin D and glycosylated albumin (GA) levels in patients with gestational diabetes mellitus (GDM) and analyze the relationship between them. Methods A total of 150 GDM pregnant women (a diabetes group) and 65 healthy pregnant women (a control group) who received prenatal examinations in The Obstetrics Department of Xuzhou Central Hospital from September 2017 to September 2018 were selected as study objects, and the vitamin D and GA levels of the two groups were detected. A correlation analysis was conducted on the relationship between vitamin D content and GA level. Results The plasma level of 25-OH-D in the pregnant women with diabetes was significantly lower than that of the control group , and the difference was statistically significant (P<0.01). The GA level of diabetic pregnant women was not correlated with the age, height, pre-pregnancy weight, gestational week of them, and was negatively correlated with the vitamin D content (P=0.021). Conclusion The plasma vitamin D content of pregnant women with GDM is significantly lower than that of healthy pregnant women. The vitamin D content is closely related to GA level. The early detection of vitamin D content can prognose the risk of GDM in pregnant women.
张明,魏杰,刘培培,梁振. 妊娠糖尿病孕妇血浆维生素D含量及糖化白蛋白水平的临床研究[J]. 中国校医, 2019, 33(9): 682-684.
ZHANG Ming, WEI Jie, LIU Pei-pei, LIANG Zhen. Clinical study on plasma vitamin D and glycosylated albumin in pregnant women with gestational diabetes mellitus. Chinese Journal of School Doctor, 2019, 33(9): 682-684.
[1] 汪小娟,马志海,林晓华,等.妊娠糖尿病孕妇糖化血红蛋白与甲状腺激素水平分析[J].河北医学,2012,18(8):1060-1063. [2] Pan J,Zhang F,Zhang L,et al. Influence of insulin sensitivity andsecretion on glycated albumin and hemoglobin A1c in pregnantwomen with gestational diabetes mellitus[J].Int J Gynaecol Obstet,2013,121(3):252-6. [3] Wang L,Gao P,Zhang M,et al. Prevalence and Ethnic Pattern ofDiabetes and Prediabetes in China in 2013[J]. JAMA,2017,3,317(24):2515-2523. [4] 李琦,马彦彦.妊娠期糖尿病的规范化治疗对妊娠结局的影响[J].中国全科医学,2012,15(26):3009-3011. [5] Ross AC,Manson JE,Abrams SA,et a1. The 2011 report ondietary reference intakes for calcium and vitamin D from theInstitute of medicine:what clinicians need to know[J].J ClinEndoerinol Metab,2011,96(1):53-58. [6] Bourlon PM,Billaudel B,Fauredussert-dussert A. Influence ofvitamin D3 deficiency and 1,25 dihydroxyvitamin D3 on de novoinsulin biosynthesis in the islets of the rat endocrine pancreas[J].JEndocrinol,1999,160(1):87-95. [7] Cade C,Norman AW. Vitamin D3 improves impaired glucosetolerance and insulin secretion in the vitamin D deficient rat in vivo[J]. Endocrinology,1986,119(1):84-90. [8] Pittas AG,Lau J,Hu FB,et a1.The role of vitamin D and calciumin type 2 diabetes. A systematic review and metaanalysis[J]. J ClinEndocrinol Metab,2007,92(6):2017-2029. [9] Holick MF,Chen TC. Vitamin D deficiency:a worldwide problemwith health consequences[J].Am J Clin Nutr,2008,87(4):1080-1086. [10] Chen J,Yun C,He Y,et a1. Vitamin D status among the elderlyChinese poulation:across-sectional analys of the 2010-2013 chinanational nutrition and health survey (CNNHS)[J].Nutr J,2017,16(1):3. [11] Li M,Lv F,Zhang Z,et a1. Establishment of a normalreference value of parathyroid hoermone in a large healthy Chinesepopulation an devaluation and bone mineral density[J].OsteoporosInt,2016,27(5):1907-1916. [12] 徐少华,赵静,朱琳,等. HBeAg阳性慢性乙型肝炎患者大量输血后其血清标志物变化研究[J].现代检验医学杂志,2017,32(6):147-150. [13] 剂芳芳,孟海霞.不同种族/民族间妊娠期糖尿病的危险因素分析[J].医学综述,2017,23(6):1196-1200. [14] 徐少华,应军,谢晓霞,等.利可君改善仅干扰素诱导的慢性乙型肝炎患者血小板减少的临床疗效研究[J].国际病毒学杂志,2014,21(5):202-205.
2019, Vol. 33 
