目的 通过流行病学调查,分析女性无先兆偏头痛的相关因素,为女性无先兆偏头痛的防治提供理论依据。方法 将女性原发性头痛的96例患者分为无先兆的月经相关性偏头痛(MRM)组、无先兆的单纯月经性偏头痛(PMM)组、月经性无先兆偏头痛(NMM)组共3个组,观察患者的一般资料,包括年龄、病程(年)、家族史(直系亲属);头痛性质:头痛的严重程度、发作频率、持续时间;共病(情绪改变)及伴随症状。所得数据用SPSS15.0软件包进行统计,计数资料行χ2检验,计量资料行t检验,多个组间比较采用单因素方差分析。结果 ⑴MRM组、PMM组患者家族史阳性率高于NMM组,差异有统计学意义(χ2=10.541,P<0.01),MRM组、PMM组患者重度疼痛阳性率高于NMM组,差异有统计学意义(χ2=9.264,P<0.05);⑵MRM组和PMM组头痛程度VAS评分、持续时间均高/长于NMM组(P<0.05),NMM组患者发作频率低于MRM组发作频率(P<0.01)。结论 女性月经性偏头痛患者家族史、重度疼痛阳性率及疼痛程度、发作频率,持续时间高/长于非月经性头痛,对指导女性无先兆偏头痛的防治有重要意义。　

Objective To investigate the factors related to woman migraine without aura, so as to provide the reference for improving the prevention and treatment of woman migraine without aura. Methods A total of 96 female cases of primary headache were divided into a MRM group, PMM group and NMM group. The general data of the patients were collected, including the age, duration (year), family history (immediate family); headache (the severity of headache, onset frequency, duration); co-morbidity (mood change) and concomitant symptoms. The data were analyzed by SPSS15.0 software package. Results ⑴The positive rates of family history of the MRM and PMM groups were significantly higher than that of the NMM group (χ2=10.541, P<0.01), and the positive rates of severe pain of the MRM and PMM groups was significantly higher than that of the NMM group, (χ2=9.264, P<0.05). (2) The VAS scores of headache and the time of duration of the MRM and PMM groups were higher/longer than those of the NMM group (P<0.05), while the frequency of the NMM group was lower than that of the MRM group (P<0.01). Conclusion The family history of menstrual migraine in women, the positive rate of severe pain, the degree of pain, the frequency of seizures, and the duration of seizures are higher/longer than those of non-menstrual headaches, which is of great significance to guide the prevention and treatment of women migraine without aura.