康复新液联合盐酸米诺环素软膏治疗慢性牙周炎疗效的Meta分析

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摘要目的系统评价康复新液联合盐酸米诺环素治疗慢性牙周炎的疗效及安全性,为临床治疗提供循证参考。方法检索2015—2020年PubMed、Cochrane、CNKI、WanFang Data等数据库,收集康复新液联合盐酸米诺环素对照盐酸米诺环素的临床试验资料。采用Cochrane系统评价对文章进行质量评估,利用RevMan 5.3软件对所纳入的研究进行Meta分析。结果最终纳入16篇随机对照研究,Meta分析结果显示,试验组临床总有效率明显优于对照组[RR=1.22,95%CI(1.16～1.28),P<0.001];试验组白细胞介素-8 [SMD=-2.04,95%CI(-2.88～-1.19),P<0.001]、牙周袋深度[SMD=-2.98,95%CI(-3.66～-2.30),P<0.001]、肿瘤坏死因子-α[SMD=-1.29,95%CI(-1.52～-1.05),P<0.001] 均低于对照组;2组不良反应发生率差异无统计学意义[RR=0.76,95%CI(0.41～1.43),P=0.40]。结论临床上给予慢性牙周炎患者康复新液与米诺环素联合治疗效果显著,具备安全性,可改善患者临床症状。　

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	贾俊琦
	吴奇憧
	李易洲
	李喃君
	王鹏来

关键词 ：慢性牙周炎, 康复新液, 盐酸米诺环素, Meta分析

Abstract：Objective To systematically evaluate the efficacy and safety of Kangfuxin liquid combined with minocycline hydrochloride in the treatment of chronic periodontitis, to provide evidence-based reference for clinical treatment. Methods PubMed, Cochrane, CNKI, WanFang Data, and other databases were searched from 2015 to 2020 to collect clinical trial data on Kangfuxin liquid combined with minocycline hydrochloride versus minocycline hydrochloride. A Cochrane systematic review was used to assess the quality of the articles, and a Meta-analysis of the included studies was performed by using RevMan 5.3 software. Results A total of 16 randomized controlled studies were included, and the results of Meta-analysis showed that the total clinical effective rate of the experimental group was significantly better than that of the control group ; In the experimental group, interleukin-8 , periodontal pocket depth , tumor necrosis factor-α . There was no significant difference in the incidence of adverse reactions between the two groups . Conclusion The combination of Kangfuxin liquid and minocycline in patients with chronic periodontitis has a significant clinical effect, is safe, and can improve the clinical symptoms of patients.

Key words： Chronic periodontitis Kangfuxin liquid Minocycline hydrochloride Meta-analysis

收稿日期: 2023-03-17

ZTFLH:

R781

作者简介: 贾俊琦(2002—),女,山东兰山人,本科在读,研究方向为牙周疾病。

引用本文:

贾俊琦,吴奇憧,李易洲,李喃君,王鹏来. 康复新液联合盐酸米诺环素软膏治疗慢性牙周炎疗效的Meta分析[J]. 中国校医, 2024, 38(1): 48-53.
JIA Junqi, WU Qichong, LI Yizhou, LI Nanjun, WANG Penglai. Meta-analysis of efficacy of Kangfuxin liquid combined with minocycline hydrochloride ointment in treatment of chronic periodontitis. Chinese Journal of School Doctor, 2024, 38(1): 48-53.

链接本文:

https://www.zgxyzz.org.cn/CN/ 或 https://www.zgxyzz.org.cn/CN/Y2024/V38/I1/48

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