Objective To analyze the epidemiological characteristics of pulmonary tuberculosis (PTB) in Guanyun County in recent years, so as to provide scientific evidence for the prevention and control of PTB. Methods Data of the epidemic of PTB in Guanyun County from 2015 to 2021 were collected, then the gender, age, occupation, and regional distribution of the patients as well as the onset time of PTB, drug resistance, and complicated extrapulmonary tuberculosis (TB) were described and compared between the groups. Results A total of 1 871 cases of PTB were reported in Guanyun County from 2015 to 2021, and the incidence decreased from 34.63/105 to 20.45/105, with an annual incidence of 25.78/105. There were PTB cases reported every month, and the proportion in each month fluctuated from 5.83% to 10.53%, with the highest proportion (10.53%) in April of the second quarter. The incidence of TB was higher in males than that in females and there was a statistical difference between the 2 sex groups (37.50/105 vs 12.71/105; χ2=431.22, P<0.001). The patients with this disease aged from 11 to 92 years, and the age of onset showed double peaks: young adults aged ≥20-30 years and the elderly aged ≥70-80 years, respectively. The proportion of PTB (73.06%) was the highest among farmers, and the incidence of PTB (118.03/105) was the highest on the Wutu River farm. It was also found that there were 2.89% of rifampicin-resistant TB, 6.57% of isoniazid-resistant TB, and 9.19% of PTB complicated with extrapulmonary TB. Conclusions The incidence of TB in Guanyun County shows a downward trend from 2015 to 2021, but there are a number of cases of rifampicin- or isoniazid-resistant TB, and extrapulmonary TB. Therefore, targeted prevention and intervention should be carried out in high-risk populations to reduce the occurrence of drug-resistant PTB.
Key words
pulmonary tuberculosis (PTB) /
epidemiological characteristic /
prevention and control
{{custom_keyword}} /
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] 王前,李涛,杜昕,等. 2015—2019年全国肺结核报告发病情况分析[J].中国防痨杂志,2021,43(2):107-112.
[2] 罗一婷,翁榕星,周芳,等. 2019 WHO全球结核报告:全球与中国关键数据分析[J].新发传染病电子杂志,2020,5(1):47-50.
[3] 任坦坦,邓国防,付亮,等. 2020 WHO全球结核报告:全球与中国关键数据分析[J].新发传染病电子杂志,2020,5(4):280-284.
[4] 舒薇,孙玙贤,张立杰,等.结核病的研究与创新—2021年世界卫生组织全球结核病报告解读[J].中国防痨杂志,2022,44(1):45-48.
[5] 中华医学会,中华医学会杂志社,中华医学会全科医学分会,等.肺结核基层诊疗指南(实践版·2018)[J].中华全科医师杂志,2019,18(8):718-722.
[6] 陈守娟,单永梅,严春华.灌云县 2010—2014 年肺结核流行特征分析[J].系统医学,2017,2(17):9-11,14.
[7] 冯宗欣,贾会英. 2014—2018年濮阳市学生肺结核流行特征分析[J].中国校医,2021,35(3):195-196,204.
[8] 贾意国,王美花,李怀臣,等. 2006—2015年济南市肺结核流行特征分析[J].山东医药,2018,58(37):71-73.
[9] 陈蕊明,彭东东,纪丽微,等. 2011—2015年广东省汕头市结核病流行病学特征及DOTS策略评价[J].实用预防医学,2017,24(5):602-604.
[10] Margalit I,Block C,Mor Z. Seasonality of tuberculosis in Israel,2001-2011[J]. Int J Tuberc Lung Dis,2016,20(12):1588-1593.
[11] Wani T,Bua S,Khude S,et a1. Evaluation of sulphonamide deriv-atives acting as inhibitors of human carbonic anhydrase isoformsI,II and Mycobacterium tuberculosis β-class enzyme Rv3273[J].J Enzyme Inhib Med Chem,2018,33(1):962-971.
[12] 周喆,郁晞,黎桂福,等.上海市青浦区2005—2020年肺结核流行特征分析[J].健康教育与健康促进,2021,16(4):404-407.
{{custom_fnGroup.title_en}}
Footnotes
{{custom_fn.content}}