Abstract:Objective To investigate the effects of the combination strategy (dapagliflozin + fosinopril) in the treatment of hypertensive patients with diabetes, on its antihypertensive, hypoglycemic, and control of the risk of heart failure. Methods A total of 120 patients with hypertension and diabetes mellitus who visited a hospital from November 2020 to August 2021 were selected and divided into 60 cases in the observation group and control group respectively by the random number table method. The control group was treated with single fosinopril, and the observation group was treated with dapagliflozin plus fosinopril for 2 months. The blood pressure control indexes , glycemic control indexes , ventricular remodeling related parameters , and heart failure incidence rates were compared between the two groups. Results Before treatment, there was no significant difference between the two groups (P>0.05). The FBG and HbA1c in the post-treatment observation group were (7.11±1.47) mmol/L and (7.22±1.52)%, respectively, which were lower than those in the control group: (7.93±2.05) mmol/L and (8.14±1.67)%, respectively (t=2.518, 3.156, P<0.05). After treatment, the 24 h SBP and 24 h DBP in the observation group were (126.35±5.41) mmHg and (75.49±4.37) mmHg, respectively, which were lower than those in the control group: (130.03±5.56) mmHg and (84.29±5.18) mmHg, respectively (t=3.674, 10.058, P<0.05). The incidence rates of heart failure in the observation group and the control group were 0.00% and 3.33%, respectively, and the incidence rates of adverse reactions in the observation group and the control group were 6.67% and 5.00%, respectively (both P>0.05). Conclusion The combined strategy (dapagliflozin + fosinopril) has a significant clinical effect in the treatment of hypertension with diabetes, which can control the risk of heart failure, and effectively lower blood sugar and blood pressure.
战玲,宋杰,杨姗姗. 达格列净联合福辛普利治疗高血压合并糖尿病的效果分析[J]. 中国校医, 2022, 36(12): 948-951.
ZHAN Ling, SONG Jie, YANG Shan-shan. Effect of dapagliflozin combined with fosinopril on treatment of hypertension and diabetes. Chinese Journal of School Doctor, 2022, 36(12): 948-951.