Abstract：Objective To explore the application value of ultrasound-guided quadratus lumbosacral block (QLB) combined with propofol anesthesia in patients undergoing abdominal radical resection of colorectal cancer (CRC). Methods Eighty-two patients with abdominal CRC radical operation in our hospital were selected and divided into two groups according to the random number table method, with 41 cases in each group. The control group was given traditional spinal anesthesia combined with propofol anesthesia, while the study group was given QLB combined with propofol anesthesia under ultrasound guidance. The stress response, hemodynamics, analgesic effect, postoperative recovery, and adverse reactions were compared between the two groups. Results One hour after anesthesia, the cortisol (Cor) and epinephrine (E) in the study group were lower than those in the control group: , respectively and the differences were statistically significant (t=3.055, 4.621, P=0.003,<0.001). The heart rate (HR) and mean arterial pressure (MAP) in the study group were higher than those in the control group at 5 minutes (T2), 2 hours (T3), and end of the operation (T4) (the differences were 5.2 beats/min, 5.74 beats /min, 5.37 beats /min and 6.58mmHg, 6.67mmHg, and 5.67mmHg), respectively. The visual analogue scale (VAS) in the study group was lower than that in the control group at different time points after the operation (the differences were 0.44, 0.48, 0.56, and 0.41 respectively), and the differences were statistically significant (P<0.001). The recovery time, the first anal exhaust time, the first time to get out of bed, and the hospitalization time in the study group were shorter than those in the control group (the differences were 5.03 min, 7.58 h, 6.71 h, and 1.09 d), respectively and the differences were statistically significant (P<0.001). The incidence of adverse reactions was 4.88% in the study group, which was lower than that in the control group:19.51% and the difference was statistically significant (χ2=4.100, P=0.043). Conclusions Ultrasound-guided QLB combined with propofol anesthesia has a good analgesic effect, which can reduce the stress of patients undergoing abdominal CRC radical operation, maintain the stability of hemodynamics during operation, facilitate postoperative recovery, and has high anesthesia safety, which is worthy of clinical application.
2023, Vol. 37 
