Abstract：Objective To explore the effect of nicergoline on neurocytokines and event-related potential in elderly patients with acute cerebral infarction. Methods A total of 127 elderly patients with acute cerebral infarction in our hospital from July 2019 to December 2020 were selected as the research objects, and they were divided into two groups by the random number table method. All the patients were treated with conventional treatment. Totally 63 cases in the control group were treated with vinpocetine, while 64 cases in the observation group were treated with nicergoline. Cognitive function, neurocytokines, motor function, event-related potential, and adverse reactions were investigated and compared between the two groups. Results After treatment, the scores of Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) in the two groups were higher than those before treatment, and the scores of MMSE and MoCA in the observation group were higher than those in the control group. After treatment, MMSE scores and MoCA scores of the control group were (24.36±4.74) points and (16.58±4.63) points respectively, and MMSE scores and MoCA scores of the observation group were (27.58±3.48) points and (18.74±5.34) points respectively, and the MMSE scores of the two groups were compared, F=4.358, P<0.001, and the MoCA scores were compared, F=2.434, P=0.016. After treatment, the levels of serum nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), and Fugl-Meyer Scale (FMA) score in the two groups were higher than those before treatment, and the levels of NGF, BDNF and FMA score in the observation group were higher than those in the control group. After treatment, the levels of NGF, BDNF and FMA scores of the control group were (8.85±0.78) ng/L, (13.23±1.45) ng/L, and (45.87±6.34), respectively, the levels of NGF, BDNF, and FMA scores in the observation group were (13.23±1.66) ng/L, (17.67±2.03) ng/L and (58.28±6.24), respectively, and the comparison of NGF level between the two groups after treatment was F=19.077, P<0.001, and the comparison of BDNF level was F=14.200, P<0.001, the comparison of FMA score was F=11.117, P<0.001. After treatment, the amplitude of P300 was increased and the latency of P300 was decreased in the two groups compared with before treatment. The amplitude of P300 in the observation group was higher than that in the control group, and the latency of P300 was lower than that in the control group. After treatment, the P300 amplitude and latency were (4.57±1.53) μV and (331.36±15.32) ms in the control group, and (5.74±1.48) μV and (308.32±14.55) ms in the observation group, respectively. After treatment, the amplitude of P300 was compared between the two groups, F=4.380, P<0.001, and the latency of P300 was compared between the two groups, F=8.691, P<0.001. There were few adverse effects and no difference between the two groups. Conclusion Vinpocetine combined with nicergoline in the treatment of elderly patients with cerebral infarction can improve cognitive function, neurocytokine levels, shorten P300 latency, increase P300 amplitude, improve motor function, and has high safety.
范艳秋,李明鑫,张云贺. 尼麦角林对127例急性脑梗死老年患者神经细胞因子的影响[J]. 中国校医, 2023, 37(4): 299-302.
FAN Yanqiu, LI Mingxin, ZHANG Yunhe. Effects of nicergoline on neurocytokines in 127 elderly patients with acute cerebral infarction. Chinese Journal of School Doctor, 2023, 37(4): 299-302.
2023, Vol. 37 
