Abstract：Objective To analyze the relationship between serum alanine aminotransferase (ALT) level and hyperuricemia. Methods The subjects were 11 858 freshmen who participated in the physical examination in October 2021. The demographic characteristics, height, weight, blood pressure, and other physical examination data were collected, and the levels of fasting serum ALT, uric acid, creatinine, etc. were detected. The logistic regression model and generalized additive model were used to analyze the relationship between serum ALT levels and hyperuricemia. Results A total of 11 858 college students were enrolled, with an average age of (21.9±4.5) years. Among them, 5 907 were male (49.8%) and 314 were hypertensive (2.7%). Hyperuricemia was detected in 3 372 cases (28.4%), and the uric acid level and hyperuricemia detection rate increased with the increase in serum ALT level. The results of the multivariate logistic regression model showed that ALT level was positively correlated with the risk of hyperuricemia, whether grouped by quartile of ALT level or by a continuous variable. OR (95% CI) values were 3.24 (2.80 - 3.76) (Q4 vs Q1) and 2.12 (1.97 - 2.29), respectively. The generalized additive model analysis found that the correlation was linear. Conclusion High serum ALT level is independently associated with an increased risk of hyperuricemia.
郭丽,张秀花,朱旻. 2021年某高校新生体检血清谷丙转氨酶与高尿酸血症的关联研究[J]. 中国校医, 2022, 36(11): 811-813,823.
GUO Li, ZHANG Xiu-hua, ZHU Min. Study on relationship between serum alanine aminotransferase and hyperuricemia in physical examination of freshmen in a university in 2021. Chinese Journal of School Doctor, 2022, 36(11): 811-813,823.
2022, Vol. 36 
