Abstract：Objective To assess the effectiveness and safety of salbutamol in the treatment of threatened abortion. Methods Randomized controlled trials (RCTs) or quasi-randomized controlled trials involving salbutamol for threatened abortion before 20 weeks were collected from MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and CNKI. The quality of the retrieved trials was assessed by the Jadad Scale and the trials in accordance with the criteria were conducted for meta-analyses with the Cochrane Collaboration's RevMan 4. 2 software. Results All of 3 RCTs from China were included, and the scores of them were less than 3. None of the 3 RCTs mentioned the method of randomization, allocation concealment, or the long-term effect, and only 1 RCT used the double blind method. Compared with the traditional Chinese medicine, salbutamol was less effective in the treatment of threatened abortion (OR=0. 16, 95% CI 0. 05 to 0. 48). The occurrence rate of adverse reactions of the salbutamol group was significantly higher than that of the traditional Chinese medicine group. Conclusion Compared with the traditional Chinese medicine for threatened abortion, salbutamol has no obvious advantages. The evidences of salbutamol in the treatment of threatened abortion are not enough.
邵云,任艳丽,郭华. 沙丁胺醇治疗先兆流产的系统评价[J]. 中国校医, 2017, 31(11): 815-817.
SHAO Yun, REN Yan-li, GUO Hua. System evaluation of salbutamol in treatment of threatened abortion. Chinese Journal of School Doctor, 2017, 31(11): 815-817.
2017, Vol. 31 
