Abstract:Objective To investigate the preventive effect and safety of low-dose tirofiban in early neurological deterioration (END) after acute ischemic stroke (AIS) intravenous thrombolysis (IVT). Methods From July 2017 to September 2019, 144 patients with AIS who received intravenous thrombolysis with alteplase in a hospital, and no intracranial hemorrhage was found after re-examination of head CT 1 h after thrombolysis and then decided whether to use tirofiban antiplatelet therapy according to the wishes of patients and their families, which were divided into an observation group and a control group. The baseline data, END, symptomatic intracerebral hemorrhage (sICH), the incidence of systemic bleeding, and mortality were compared between the two groups. The prognoses of patients in both groups at 3 months after IVT were assessed. Results The incidence of END in the observation group was 7.87% and 20.00% in the control group, and the difference was statistically significant (χ2=4.576, P=0.032). There were no significant differences in sICH, systemic bleeding, and mortality between the observation group and the control group (all P>0.05). CPI was present in 85.39% (76/89) of patients in the observation group 24 hours after intravenous thrombolysis, and 70.91% (39/55) in the control group, and the difference between the two groups was statistically significant (χ2=4.434, P=0.035). DFI occurred in 2 cases in the observation group and 9 cases in the control group, and the difference was statistically significant (χ2=9.601, P=0.002). After 3 months of intravenous thrombolysis, the good prognosis rate was 70.79% in the observation group and 52.73% in the control group, and the difference was statistically significant (χ2=4.805, P=0.028). Conclusion The early combination of intravenous thrombolysis combined with low-dose tirofiban in the treatment of AIS is safe and effective, which can significantly reduce the deterioration of early neurological function, and the short-term prognosis is good.
孙锋,李会晓,崔炎增. 小剂量替罗非班治疗急性缺血性脑卒中溶栓后早期神经功能恶化的效果[J]. 中国校医, 2024, 38(1): 54-57.
SUN Feng, LI Huixiao, CUI Yanzeng. Effect of low-dose tirofiban in treatment of early neurological deterioration after thrombolysis in acute ischemic stroke. Chinese Journal of School Doctor, 2024, 38(1): 54-57.