硫酸镁联合布地奈德及特布他林对毛细支气管炎患儿血清炎性因子水平的影响

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摘要目的探讨硫酸镁与布地奈德及特布他林联合对毛细支气管炎患儿血清炎性因子水平的影响。方法选取2017年1月—2019年1月某院收治的毛细支气管炎患儿80例,按随机数字表法分为两组,各40例,对照组采用地塞米松联合布地奈德及特布他林治疗,观察组在此基础上加用硫酸镁治疗。比较两组治疗效果、炎性因子水平及肺功能。结果治疗后,观察组白介素-6为(60.32±6.11)pg/mL、降钙素原为(0.80±0.26)μg/L、肿瘤坏死因子-α为(1.56±0.54)ng/mL、C-反应蛋白为(5.02±0.41)mg/L,均低于对照组[(85.14±8.25)pg/mL、(1.71±0.41)μg/L、(2.64±0.42)ng/mL、(8.04±0.56)mg/L],(P值均<0.05);治疗后,观察组呼吸频率为(28.65±4.32)次/min、有效呼吸道阻力为(2.98±1.17)kPa/(L/S)、功能残气量为(134.85±35.41)mL,低于对照组[(31.22±6.45)次/min、(4.52±2.44)kPa/(L/S)、(171.78±41.58)mL],潮气量(VT)(7.04±1.05)mL/kg高于对照组(6.42±1.01)mL/kg,(P<0.05)。结论硫酸镁联合布地奈德及特布他林可有效改善毛细支气管炎患儿临床症状,降低炎性因子水平,改善肺功能,值得进一步推广。　

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关键词 ：婴幼儿, 细支气管炎, 硫酸镁, 布地奈德, 特布他林, 肿瘤坏死因子-α, C反应蛋白

Abstract：Objective To explore the effect of magnesium sulfate combined with budesonide and terbutaline on serum inflammatory factors in children with bronchiolitis. Methods Totally 80 inpatients with bronchiolitis were selected in a hospital from January 2017 to January 2019 according to the random number table method, and they were divided into a control group and a trial group, with 40 cases in each group. The patients in the control group were used dexamethasone combined budesonide and terbutaline, and the patients in trial group received magnesium sulfate on the basis of control group's treatment. The therapeutic effects, inflammatory factor levels and lung function were compared between two groups. Results After the treatment, in the trial group, the average level of leymesin-6 (IL-6) was (60.32±6.11) pg/mL, the level of procalcitonin (PCT) was (0.80±0.26) μg/L, the level of tumor necrosis factor-α (TNF-α) was (1.56±0.54) ng/mL, and the level of C-reactive protein (CRP) was (5.02±0.41) mg/L, which were lower than those in the control group . After the treatment, in the trial group, the respiratory rate (RR) was (28.65±4.32) sub/min, effective respiratory resistance (Reff) was (2.98±1.17) kPa/(L/S), and functional residual gas (FRC) was (134.85±35.41) ml, which were lower than those in the control group . After the treatment, in the trial group, the tide volume (VT) was (7.04±1.05) ml/kg, which was higher than that in the control group . Conclusion The treatment of magnesium sulfate combined with budesonide and terbutaline can effectively improve the clinical symptoms of children with bronchiolitis, reduce the levels of inflammatory factors, improve the lung function, and it is worthy of further promotion.

Key words： infants bronchiolitis magnesium sulfate budesonide terbutaline tumor necrosis factor-alpha (TNF-α) C-reactive protein (CRP)

收稿日期: 2019-08-09

ZTFLH:

R725.6

作者简介: 熊蕾蕾(1989-),河南信阳人,住院医师,硕士,研究方向为小儿呼吸道疾病。

引用本文:

熊蕾蕾,李会娟,常会娟,靳秀红. 硫酸镁联合布地奈德及特布他林对毛细支气管炎患儿血清炎性因子水平的影响[J]. 中国校医, 2020, 34(10): 764-766.
XIONG Lei-lei, LI Hui-juan CHANG Hui-juan, JIN Xiu-hong. Effect of magnesium sulfate combined with budesonide and terbutaline on serum inflammatory factors in children with bronchiolitis. Chinese Journal of School Doctor, 2020, 34(10): 764-766.

链接本文:

https://www.zgxyzz.org.cn/CN/ 或 https://www.zgxyzz.org.cn/CN/Y2020/V34/I10/764

[1] 张季红,张晓英,孙光辉,等.毛细支气管炎患儿医院感染的病原学与抗感染治疗效果[J].中华医院感染学杂志,2016,26(11):2587-2589.
[2] 兰伟平,王婧,代传林.丙酸氟替卡松气雾剂或布地奈德混悬液干预对毛细支气管炎反复喘息的疗效观察[J].中国当代儿科杂志,2016,18(4):316-319.
[3] 欧有平.孟鲁斯特钠联合布地奈德和复方异丙托溴铵治疗婴幼儿毛细支气管炎的疗效观察[J].现代药物与临床,2016,31(3):375-378.
[4] 马科,卢蓉,寇艳,等.利巴韦林联合布地奈德雾化吸入治疗小儿毛细支气管炎的临床疗效及其对血清白介素4、干扰素γ水平的影响研究[J].实用心脑肺血管病杂志,2016,24(3):31-34.
[5] 郝凤清.布地奈德联合特布他林雾化吸入治疗毛细支气管炎疗效观察[J].中国药物与临床,2018,18(3):451-452.
[6] 李双全,王建忠,杨帆,等.布地奈德联合特布他林治疗婴幼儿毛细支气管炎对肺功能及再次喘息的影响[J].儿科药学杂志,2018,24(06):29-32.
[7] 孙洪华,李文华.硫酸镁联合甲泼尼龙治疗小儿毛细支气管炎的临床研究[J].现代药物与临床,2018,33(3):541-545.
[8] 陈小茹,钟伟成.高渗盐水吸入治疗急性毛细支气管炎的疗效和安全性研究[J].中国校医,2018,32(6):455,457.
[9] 隋登宇.单磷酸阿糖腺苷联合布地奈德治疗小儿毛细支气管炎的临床研究[J].现代药物与临床,2017,32(2):241-244.
[10] 刘秋云,李黎辉,张和成.干扰素、布地奈德和特布他林联合治疗小儿喘息性支气管炎疗效观察[J].河北医药,2017,39(3):431-433.
[11] 宋有标,张新雅.硫酸镁联合布地奈德、硫酸特布他林雾化吸入治疗毛细支气管炎疗效简[J].昆明医科大学学报,2016,37(9):71-75.
[12] 史军然,薛红霞,白瑞珍,等.硫酸镁联合干扰素α-1b雾化吸入治疗重症毛细支气管炎的效果分析[J].河北医科大学学报,2016,37(1):89-91.