Abstract：Objective To evaluate the clinical efficacy of Wuweiningshi (a traditional Chinese medicine preparation) in the treatment of ureteral calculi after extracorporeal shock wave lithotripsy (ESWL). Methods A total of 80 patients with ureteral calculi who were treated with extracorporeal shock wave lithotripsy in a hospital from 2018.08 to 2019.08 were randomly divided into a trial group (n=40) and a control group (n=40) according to the Excel random number table method. The patients in the control group were given more water and more activities after the operation, and the patients in the trial group were given Wuweiningshi on the basis of encouraging patients to drink more water and appropriate more activities. The treatment was observed for 4 weeks. The effective stone excretion rate was evaluated after one week. The PH value of urine and the contents of citric acid and oxalic acid in urine were measured after four weeks. Results The total effective rate of ureteral calculi after ESWL in the trial group was 92.5%, which was higher than that in the control group (72.5%). After 4 weeks, the urine PH value (6.3±0.6) and the content of urinary citric acid in the trial group were higher than before the treatment (5.9±0.7), while the content of urinary oxalic acid decreased (all P<0.05). Conclusion Wuweiningshi can promote the efficiency of excretion of ureteral calculi after ESWL, increase the contents of urinary PH and urinary citric acid, reduce the content of urinary oxalic acid, and effectively prevent the recurrence of calcium oxalate calculi.
马伟明,卢子杰,王希涛,蒋博,张俊杰,董洋,周家合,庞昆,韩从辉. 五味宁石中药在体外冲击波碎石治疗输尿管结石术后应用效果评价[J]. 中国校医, 2020, 34(3): 184-186,226.
MA Wei-ming, LU Zi-jie, WANG Xi-tao, JIANG Bo, ZHANG Jun-jie, DONG Yang, ZHOU Jia-he, PANG Kun, HAN Cong-hui. Clinical efficacy of Wuweiningshi combined with extracorporeal shock wave lithotripsy in treatment of ureteral calculi. Chinese Journal of School Doctor, 2020, 34(3): 184-186,226.
[1] 叶章群.泌尿系结石研究现况与展望[J].中华实验外科杂志,2005,22(3):261-262. [2] 朱建宁,唐犇,张加桥,等.富马酸二甲酯对大鼠肾草酸钙结石形成的影响及机制[J].中华实验外科杂志,2019,36(8):1433-1436. [3] 陈曙辉,林煦垚,张明强,等.中医药治疗石淋病的研究进展[J].云南中医中药杂志,2019,40(2):76-78. [4] 张泽,欧莉莉,曾国华,等.离子色谱法同时测定24小时尿草酸和枸橼酸的应用价值[J].中华泌尿外科杂志,2007,28(1):75-77. [5] 周向文,黄冬梅.泌尿系结石的治疗进展[J].中国误诊学杂志,2010,10(15):129-132. [6] Assimos DG. Re:Metabolic Evaluation and Recurrence Prevention for Urinary Stone Patients: EAU Guidelines[J].J Urol,2015,193(6):2008-2009. [7] 胡卫国,李建兴,叶章群. 2019年欧洲泌尿外科学会年会泌尿系结石诊治热点和进展[J].中华泌尿外科杂志,2019,40(4):251-252. [8] Chung SD,Chen YK,Lin HC. Increased risk of diabetes in patients with urinary calculi: a 5-year followup study[J]. J Urol, 2011,186(5):1888-1893. [9] Kimura S,Kawaguchi Y,Momozono K,et al. Female urethral divert-iculum containing large calculi [J]. Urol Case Rep,2018,18:(14-5). [10] Hattori CM,Tiselius HG,Heilberg IP. Whey protein and albumin effects upon urinary risk factors for stone formation[J]. Urolithia-sis. 2017,45(5):421-428. [11] Campos AH,Schor N. Phyllanthus niruri inhibits calcium oxalate endocytosis by renal tubular cells: its role in urolithiasis[J].Nephron,1999,81(4):393-397. [12] Freitas AM,Schor N,Boim MA. The effect of Phyllanthus niruri onurinary inhibitors of calcium oxalate crystallization and other factors associated with renal stone formation[J].BJU Int,2002,89(9):829-834. [13] Grases F,Ramis M,Costa-Bauza A,et al. Effect of Herniaria hirsuta and Agropyron repens on calcium oxalate urolithiasis risk in rats[J].J Ethnopharmacol,1995,45(3):211-214. [14] Yasui T,Fujita K,Sato M,et al. The effect of takusha,a kampomedicine, on renal stone formation and osteopontin expression in a rat urolithiasis model[J]. Urol Res,1999,27(3):194-199. [15] 邓芳,罗旭彪,曾桂生,等.植物药治疗泌尿系结石的研究进展[J].中草药,2007,38(8):1272-1276. [16] 张志伟,孙西钊.植物药预防尿路结石[J].东南大学学报(医学版),2005,24(2):118-121.
2020, Vol. 34 
